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KMID : 1147520090020010001
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Korean Academy of Basic Medicine & Health Science
2009 Volume.2 No. 1 p.1 ~ p.6
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Animal Model upon Thoracic Aortic Banding Induced Pressure Overloaded Cardiac Hypertrophy
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Song Jong-Wook
Lee Sang-Kil
Park Soo-Kyoung
Lee Young-Jeon
Lee Han-Ki
Hong Yong-Geun
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Abstract
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Hypertrophic transformation is important in many forms of heart disease including ischemia, hypertension, heart failure, and valvular disease. In each of these types of cardiac pathology, hypertrophy has a crucial compensatory function normalizing wall stress and oxygen consumption. At the same time, hypertrophy may be an early phase in a pathogenic process that culminates in heart failure. The molecular signaling pathways involved in the pathogenesis of hypertrophy and transition to heart failure are the subject of intense investigation. To establish the cardiac hypertrophic animal model, we performed the microsurgery of thoracic aortic banding (TAB) under stereomicroscope, the systolic blood pressure of TAB-operated mice and their control sham-operated mice were measured using tail cuff plethysmography at 3 weeks after microsurgery. The systolic blood pressure was increased at 3 week after TAB microsurgery compared to sham (145 vs. 105 mmHg). These results suggest that TAB-operated animal model might be available to investigate of cardiogenic hypertension based on cardiac hypertrophy
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KEYWORD
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Animal model, Cardiac hypertrophy, Hypertension, Thoracic aortic banding (TAB)
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